Identification of new risk factor for nonB, nonC hepatocellular carcinoma: Global analysis using GWAS and data-mining analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kurume University
• Principal Investigator: Sata Michio 久留米大学, 先端癌治療研究センター, 教授 (10162398)
• Co-Investigator(Kenkyū-buntansha): Kawaguchi Takumi 久留米大学, 医学部, 講師 (00320177) ; Kawaguchi Atsushi 佐賀大学, 医学部, 教授 (60389319) ; Yamada Shingo 久留米大学, 医学部, 助教 (50425188)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝臓がん / 遺伝子異常 / 代謝異常 / 網羅的解析

Outline of Final Research Achievements

Recently, the number of patients with hepatocellular carcinoma without infection of hepatitis B and C virus (NBNC-HCC) is increasing. We aimed to identify risk factor for NBNC-HCC by GWAS and data-mining analysis. Subjects are 223 NBNC-HCC patients and 669 healthy subjects. We demonstrated that serum level of gamma-GTP, Brinkman index, and serum level of albumin were independent risk factor for NBNC-HCC. We also found that variant（I148M）of patatin-like phospholipase domain containing 3 gene（PNPLA3） is frequently seen in patients with NBNC-HCC.

Free Research Field

消化器病学