The functional role of chromatin remodeling regualtor Brg1 in pancreatic cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461021
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Fukuda Akihisa 京都大学, 医学(系)研究科(研究院), 助教 (70644897)
• Co-Investigator(Renkei-kenkyūsha): SENO HIROSHI 京都大学, 医学研究科, 教授 (90335266)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵癌 / マウスモデル

Outline of Final Research Achievements

Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). However, little is known about molecular mechanisms of development of IPMN and IPMN-derived PDA. We have recently reported that loss of Brg1, a core subunit of SWI/SNF chromatin remodeling complexes, cooperates with oncogenic Kras to form cystic neoplastic lesions that resemble human IPMN and progress to PDA. We revealed that Brg1 is a determinant of context-dependent Kras-driven pancreatic tumorigenesis and chromatin remodeling may underlie the development of distinct PDA subsets.

Free Research Field

消化器内科学