The development of new therapeutic strategy for targeting interaction of tumor stroma in pancreatic neuroendocrine tumor

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyushu University
• Principal Investigator: ITO TETSUHIDE 九州大学, 医学(系)研究科(研究院), 准教授 (50253448)
• Co-Investigator(Kenkyū-buntansha): IGARASHI Hisato 九州大学, 大学院医学研究院・病態制御内科学, 共同研究員 (60467941)
• Research Collaborator: NIINA Yusuke ; HIJIOKA Masayuki ; LEE Lingaku
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵神経内分泌腫瘍 / 腫瘍間質相互作用 / 新規治療法 / Ki-67指数 / mTOR pathway / somatostatin受容体 / dopamine受容体 / 予後因子

Outline of Final Research Achievements

The aim of the study is to evaluate the interaction between pancreatic neuroendocrine tumor (PNET) and stromal cells, especially pancreatic stellate cells (PSCs). The degree of PSCs infiltration in stroma and intra-PNET cells was more dominant and well correlated with Ki-67 labeling index and prognosis. Furthermore, the expression of dopamine receptor was observed in approximately 30% accompanied with mTOR pathway and somatostatin receptor type 2. The degree of expression of dopamine receptor was correlated with Ki-67 labeling index and prognosis.
In conclusion, we demonstrated that the target therapy against dopamine receptor might be a new therapeutic strategy for treatment in patients with advanced PNET.

Free Research Field

消化器内科学