Clarification of autophagy mechanisms to tracking from exocrine secretory granule membrane

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kitasato University
• Principal Investigator: Kawashima Rei 北里大学, 医療衛生学部, 講師 (70392389)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Takafumi 北里大学, 医療衛生学部, 教授 (30245378) ; KAWAKAMI Fumitaka 北里大学, 医療衛生学部, 講師 (50511896)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵臓 / GP2 / オートファジー

Outline of Final Research Achievements

The aim of this study was to reveal whether the glycoprotein2 (GP2) that expressed in zymogen granule membrane of pancreatic acinar cells control the autophagy mechanism. Experiments using GP2 knockout mice, the secretion of pancreatic exocrine digestive enzymes amylase, autophagosomal film forming related protein expression and ER endoplasmic reticulum formed related protein expression were found to have been controlled by the presence or absence of GP2. In conclusion, in the process of autophagy occurs, it was considered to be GP2 molecule relevant at the time of the ER membrane provided.

Free Research Field

消化器内科学