2016 Fiscal Year Final Research Report
Novel strategy for treatment of pancreatic cancer by using EUS-FNAB samples
Project/Area Number |
25461033
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Mie University |
Principal Investigator |
Isaji Shuji 三重大学, 医学系研究科, 教授 (70176121)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 膵癌 / EUS-FNAB |
Outline of Final Research Achievements |
By using Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy (EUS-FNAB) samples, we planed to establish personalized treatment for advanced pancreatic cancer. First we evaluated the relationship between Human equilibrative nucleoside transporter (hENT1) expressions assessed by immunohistochemical staining and clinical outcomes. We could discriminate whether the patients had a sensitivity of chemotherapy (gemcitabine) or not. In addition, we investigated immunohistochemical staining of dihydropyrimidine dehydrogenase (DPD: enzyme involved in the degradation of tegafur), and we revealed that DPD was useful of chemo sensitivity for TS-1.
|
Free Research Field |
膵癌治療
|