2016 Fiscal Year Final Research Report
Cardiac nervous function and ganglionated plexi ablation in atrial fibrillation.
| Project/Area Number |
25461039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 心房細動 / 心臓交感神経 / 心臓MIBG / 心筋焼灼術 |
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| Outline of Final Research Achievements |
1) Consecutive 100 patients with paroxysmal atrial fibrillation (AF) who underwent AF ablation were enrolled. Blood samples were simultaneously collected from the left atrial (LA) and systemic circulation (SC). The prevalence of positive LA-D-dimer was greater than that of SC-D-dimer (P<0.01). LA volume index was independently correlated with positive LA-D-dimer (P=0.011). The prevalence of positive LA-D-dimer was significantly lower in patients taking continuous warfarin, than in those on discontinuous warfarin (P=0.025).
2) In 20 patients with AF who underwent 123I-MIBG imaging on the day before and several days after the ganglionated plexi ablation, there was no difference in any MIBG parameters between the values before and after the ablation
3) A total of 50 consecutive patients with paroxysmal AF were randomized to receive either landiolol or a placebo. The prevalence of immediate AF recurrence was significantly lower in the landiolol group than in the placebo group (P=0.015).
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| Free Research Field |
循環器内科
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