Prediction of drug-induced cardiomyopathy with transthoracic echocardiography and cardiac biomarkers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Watanabe Atai 東京大学, 医科学研究所, 助教 (00597271)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Naohide 東京大学, 医科学研究所, 教授 (90174680)
• Co-Investigator(Renkei-kenkyūsha): TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681) ; ISOO Naoyuki 東京大学, 医科学研究所, 助教 (80420214) ; OHNO Hideki 東京女子医科大学, 東医療センター, 講師 (30396866)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 薬剤性心筋症 / 心エコー図検査 / 左室拡張機能 / バイオマーカー

Outline of Final Research Achievements

The purpose of this study is to predict drug-induced cardiomyopathy using transthoracic echocardiography and cardiac biomarkers (BNP, high-sensitive troponin T, high-sensitive CRP, pentraxin 3 and ST2) in patients with hematologic malignancies. Of the 76 patients, 5 (6.6 %) developed drug-induced cardiomyopathy after treatments. In these patients, diastolic wall strain, a parameter of left ventricular diastolic function, was significantly decreased before treatments as compared with patients without cardiomyopathy (P = 0.04). Values of biomarkers were not associated with development of cardiomyopathy. This result suggests that a patient who has left ventricular diastolic dysfunction before treatments with anticancer agents may often develop drug-induced cardiomyopathy. Diastolic wall strain may be a useful predictor of drug-induced cardiomyopathy.

Free Research Field

循環器内科学