2016 Fiscal Year Final Research Report
Clinical Evaluation of Calcium Overload in Heart Failure
| Project/Area Number |
25461048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMINO Tohru 新潟大学, 医歯学系, 教授 (90328063)
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| Research Collaborator |
WATANABE Tohru
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 心不全 / カルシウム過負荷 / 頻度収縮性関係 / 交互脈 / 刺激後増強反応 |
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| Outline of Final Research Achievements |
In patients with heart failure, one of the main cause of myocardial systolic dysfunction is considered to be myocardial calcium overload, however there is no method to show calcium overload directly in vivo in heart failure patients. Therefore, we hypothesized that calcium overload was a condition in which the amount of calcium loaded in myocardial sarcoplasmic reticulum was too much to release effectively in a coupling interval. Then we examined patterns of change in left ventricular systolic force by changing heart rate using atrial pacing during cardiac catheterization. We found that in patients with left ventricular systolic dysfunction showed enhancement of systolic force during tachycardia was smaller than that of control although cessation of pacing and following long coupling interval enhanced systolic force significantly more than that of control. These findings and our other findings suggest calcium overload in patients with heart failure.
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| Free Research Field |
循環器内科学
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