New treatment for left ventricular diastolic failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tottori University
• Principal Investigator: Ogino Kazuhide 鳥取大学, 医学部附属病院, 准教授 (70294311)
• Co-Investigator(Renkei-kenkyūsha): HISATOME Ichiro 鳥取大学, 医学(系)研究科(研究院), 教授 (60211504)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 心不全 / 拡張不全 / インスリン抵抗性 / アルドステロン / 高血圧

Outline of Final Research Achievements

We evaluated the effects of drug therapy on insulin resistance and purine-uric acid metabolism in heart failure, and discussed the possibility of new treatment of heart failure.　We induced ischemia-reperfusion injury using AMP deaminase deficient mouse and evaluated the mechanism and the relationship between heart failure and purine-uric acid metabolism. In addition, we evaluated the effects of an aldosterone antagonist and a loop diuretic on insulin resistance and cardiac function as well as fibrosis markers and inflammation markers in patients with heart failure.
From these studies, purine-uric metabolism and insulin resistance might be targets for new treatments of heart failure.

Free Research Field

医歯薬学（循環器内科）