Crosstalk between aortic aneurysm wall and peripheral adipose tissue

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Juntendo University
• Principal Investigator: KUWAKI Kenji 順天堂大学, 医学(系)研究科(研究院), 准教授 (90398313)
• Co-Investigator(Kenkyū-buntansha): MATSUSHITA Satoshi 順天堂大学, 医学部, 准教授 (20407315)
• Co-Investigator(Renkei-kenkyūsha): AMANO Atsushi 順天堂大学, 医学部, 教授 (70338440) ; INABA Hirotaka 順天堂大学, 医学部, 准教授 (10511454) ; YAMAMOTO Taira 順天堂大学, 医学部, 准教授 (70301504)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腹部大動脈瘤 / 脂肪組織 / 炎症性サイトカイン / アディポネクチン

Outline of Final Research Achievements

Aortic aneurysm was one of the diseases caused by arteriosclerosis, which is related with chronic inflammation. Recent study demonstrated an interaction of inflammation between artery and per arterial adipose tissue. However little known about the relationship aneurysm and peri-aortic adipose tissue. In this study, we compared the cytokine expression of adipose tissue among subdermal (SD) and peri-aneurysm (PA). The adipose tissues were obtained during open abdominal aneurysm repair surgery. Expression of inflammation-related cytokines was higher in PA. Expression of M1-macrophage was also higher in PA. Expression of angiogenesis-related cytokines or fibrosis-related cytokines were not different. Furthermore, the expression of adiponectin was reduced in PA.

Free Research Field

心臓血管外科