2015 Fiscal Year Final Research Report
Noninvasive Assessment of Inflammatory Response after Coronary Stenting by 18F-
| Project/Area Number |
25461073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUMITA Shinichiro 日本医科大学, 大学院医学研究科, 教授 (70234523)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 冠動脈ステント / ステント血栓症 / 炎症反応 |
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| Outline of Final Research Achievements |
[Background] Inflammatory response has been considered to play an important role in the development of adverse events in patients who receive coronary stenting. This study aimed to determine the usefulness of 18-F fludeoxyglucose (FDG)-positron emission tomography (PET) in evaluating the regional inflammatory process after coronary stent implantation. [Method] Patients who received drug-eluting stent (DES) at proximal LAD lesion were enrolled. They underwent FDG-PET 8 weeks later and follow-up coronary arteriography with optical coherence tomography (OCT) 10 months later. [Results] There was no significant difference in NIH thickness between the patients with FDG uptake and those without. However, the incidences of uncovered strut as well as malapposed strut were significantly higher in FDG positive than in FDG negative patients. [Conclusion] FDG-PET is useful for evaluating the regional inflammatory response after DES implantation.
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| Free Research Field |
医学
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