Influence of plaque rupture and erosion on ACS; insight of optical coherence tomography-verified and integrated backscatter intravascular ultrasound-verified thin-cap fibroatheroma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Fujita Health University
• Principal Investigator: OZAKI YUKIO 藤田保健衛生大学, 医学部, 教授 (50298569)
• Co-Investigator(Kenkyū-buntansha): WATANABE EIICHI 藤田保健衛生大学, 医学部, 教授 (80343656) ; IZAWA HIDEO 藤田保健衛生大学, 医学部, 教授 (80402569)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Acute coronary syndrome / OCT / IVUS / IB-IVUS / TCFA / PCI

Outline of Final Research Achievements

Atherosclerotic plaques associated with acute coronary syndromes (ACS) on histopathological characterisation demonstrate either ruptured fibrous caps (RFC) or intact fibrous caps (IFC). The former lesions often involved thin cap fibrous atheroma (TCFA) and are responsible for up to two-third of culprit lesions in ACS patients. Although intracoronary optical coherence tomography (OCT) has a higher resolution (10µm) as compared with IVUS, and is therefore readily able to visualize thin fibrous cap and thereby identify TCFA. However, its low tissue penetration limits its ability to quantitatively assess plaque morphology. Comprehensive plaque assessment therefore currently appears to require both techniques, limiting their application in clinical practice. We evaluated the ability of a newly developed IB-IVUS system to detect OCT-verified TCFA and assessed whether this correlated with peri-procedural myocardial infarction (PMI) after PCI.

Free Research Field

循環器内科学