Cardiac iron status by T2*-weighted MRI in patients with cardiomyopathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Osaka Medical College
• Principal Investigator: Kanzaki Yumiko 大阪医科大学, 医学部, 講師 (80445999)
• Co-Investigator(Kenkyū-buntansha): ISHIZAKA Nobukazu 大阪医科大学, 医学部, 教授 (20270879) ; TERASAKI Fumio 大阪医科大学, 医学部, 教授 (20236988)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心臓MRI / T2* / 鉄代謝 / 心機能 / 心筋症

Outline of Final Research Achievements

We investigated the possible association between cardiac function and iron content in the heart and liver, estimated non-invasively by T2 star (T2*)-weighted magnetic resonance imaging. In total 218 patients were enrolled. Among those patients, 48 patients with dilated cardiomyopathy (DCM), 16 patients with hypertrophic cardiomyopathy (HCM), 7 patients with cardiac sarcoidosis and 18 patients without apparent cardiovascular abnormalities. Cardiac T2* values were lower in the DCM group and cardiac sarcoidosis group than in the HCM and control groups, although hepatic T2* values did not differ significantly across the groups. Among the whole population, the highest cardiac T2* tertile was significantly negatively associated with a low left ventricular ejection fraction of <50 %. The possibility that cardiac iron overload may have a role in reducing the systolic cardiac function in DCM patients who do not have systemic iron overload requires further investigation in the future.

Free Research Field

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