2015 Fiscal Year Final Research Report
Renal Sympathetic Denervation in Heart Failure
| Project/Area Number |
25461080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 心不全 / 不整脈 / 交感神経除神経 / カテーテルアブレーション |
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| Outline of Final Research Achievements |
We examined the physiological responses by electrical stimulation from intra- renal arteries,the histopathological distribution of peri-renal arterial nerves and effects of renal denervation in canines with heart failure. Significant physiological responses by electrical stimulation were observed in many points of intra-renal arteries. Most peri-renal arterial nerve bundles were positive stein of tyrosine hydroxylase and coexisted with positive stein of CRGP as sensory nerves. Irrigated catheter ablation in intra-renal artery effectively ablated peri-renal nerves and can be expected beneficial effects in heart failure.
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| Free Research Field |
内科系臨床医学・循環器内科学
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