Role of impaired mitochondrial function on endothelial dysfunction in cardiovascular diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University
• Principal Investigator: Sugiyama Seigo 熊本大学, 生命科学研究部, 非常勤講師 (90274711)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: endothelial function / mitochondria / AMPK / cardiovascular events / heart failure / vascular biology / atherosclerosis / endothelial cell

Outline of Final Research Achievements

Mitochondrial dysfunction plays an important role in cellular senescence and impaired function of vascular endothelium, resulted in cardiovascular diseases. AMP-activated protein kinase (AMPK) plays a critical role in mitochondrial biogenesis and endothelial function. In cultured human coronary artery endothelial cells (HCAECs), telmisartan (Telmi) significantly enhanced mitochondrial activity assessed by mitochondrial reductase activity and intracellular ATP production and increased the expression of mitochondria related genes. Telmi prevented cellular senescence and exhibited the anti-apoptotic and pro-angiogenic properties. All of these effects were abolished by inhibition of AMPK. Telmi enhanced mitochondrial activity and exhibited anti-senescence effects and improving endothelial function through AMPK in HCAECs. Telmi could provide beneficial effects on vascular diseases via enhancement of mitochondrial activity and modulating endothelial function through AMPK activation.

Free Research Field

動脈硬化、血管細胞生物学