Predictors for the progression of aortic plaques using cardiovascular imaging and biomarkers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Osaka City University
• Principal Investigator: SUGIOKA KENICHI 大阪市立大学, 大学院医学研究科, 講師 (60382149)
• Co-Investigator(Kenkyū-buntansha): UEDA MAKIKO 大阪市立大学, 大学院医学研究科, 教授 (10137193)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大動脈プラーク / 脳梗塞 / 経食道心エコー / バイオマーカー

Outline of Final Research Achievements

Progression of atherosclerotic plaques in the aorta and carotid artery is the cause of symptomatic brain infarction or thromboembolism. Therefore, it is important to clarify the predictors and mechanism of the plaque progression or destabilization in these arteries. We have reported the association of several risk factors and inflammatory or oxidative stress biomarkers with the destabilization of aortic or carotid plaques using cardiovascular imaging. In the present study, we showed that new risk factors such as chronic kidney disease or blood pressure variabilities are also closely associated with aortic plaque progression, and that advanced aortic plaques relates the presence of silent brain infarction on brain MRI.

Free Research Field

医学