2015 Fiscal Year Final Research Report
Promotion of Plaque Stability by Glucagon-like Peptide-1 Receptor Agonist: Serial In Vivo Findings
| Project/Area Number |
25461094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRO Takafumi 日本大学, 医学部, 教授 (10294638)
MITSUMATA Masako 日本大学, 医学部, 兼任講師 (40064589)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 動脈硬化 |
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| Outline of Final Research Achievements |
We investigated the effects of glucagon-like peptide-1(GLP-1)on atherosclerotic plaque in Watanabe heritable hyperlipidemic (WHHL) rabbit. The WHHL rabbits were divided into GLP-1 group or control group. GLP-1 receptor agonist was administered by osmotic pump in GLP-1 group. Same volume of normal saline was administered in control group. Atherosclerotic plaques inbrachiocephalic arteries were evaluated in vivo by Intravascular Ultrasound (IVUS) before and 12 weeks after GLP-1 receptor agonist treatment. Finally, the arteries were harvested and the atherosclerotic plaques were evaluated with pathological analysis.In comparison to control group, IVUS analysis revealed that GLP-1 receptor agonist inhibited plaque development with less plaque growth and increased plaque stability. Pathological analysis confirmed the IVUS findings with increased fibrotic content. Our study suggested that GLP-1 receptor agonist may stabilize atherosclerotic plaque.
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| Free Research Field |
循環器
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