Impact of Alogliptin on coronary plaque stability in patients with diabetes mellitus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: Kume Teruyoshi 川崎医科大学, 医学部, 講師 (60341088)
• Co-Investigator(Kenkyū-buntansha): NEISHI YOJI 川崎医科大学, 医学部, 准教授 (80319946)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 光干渉断層撮影法 / 糖尿病 / 冠動脈 / プラーク / 不安定性

Outline of Final Research Achievements

We analyzed 37 patients (51 lesions) with coronary artery disease by using optical coherence tomography (OCT). Previous histopathological studies showed that thinner fibrous cap thickness covering lipid core might be related to vulnerable plaque. We compared the change of fibrous cap thickness between patients with and without diabetes mellitus during 9 months follow-up. There was no significant difference in the change of fibrous cap thickness between the 2 groups (-9.6±33.7 vs. 8.1±43.4 μm). Clarifying the effect of DPP-4(dipeptidyl Peptidase-4) inhibitor on plaque stability might need longer follow-up period with a large number of patients.

Free Research Field

医歯薬学