2015 Fiscal Year Final Research Report
Elucidation of pathophysiological significance of glycosylation in the regulatory mechanism of BNP processing
| Project/Area Number |
25461107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAGAWA YASUAKI 京都大学, 医学(系)研究科(研究院), 助教 (70452357)
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| Co-Investigator(Kenkyū-buntansha) |
KUWAHARA KOICHIRO 京都大学, 大学院医学研究科, 講師 (30402887)
KUWAHARA KOICHIRO 京都大学, 大学院医学研究科, 非常勤講師 (80291946)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 分子心臓病学 |
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| Outline of Final Research Achievements |
O-linked glycosylation in both Thr48 and Thr71 on N-terminal region of proBNP, which is an procursor peptide of brain natriuretic peptide(BNP), plays an essential role, and glycosylation in other sites also indirectly affects in the regulatory mechanisms of processing and secretion of proBNP in the cardiac myocytes.
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| Free Research Field |
循環器病学
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