Pathophysiological mechanisms of cardiac dysfunction in the presence of renal failure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: SUZUKI Jun-ichi 東京大学, 医学部附属病院, 特任准教授 (90313858)
• Research Collaborator: WATANABE Ryo
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心腎連関 / 心筋虚血 / 腎不全

Outline of Final Research Achievements

The purpose of this study was to evaluate the effect of irbesartan on the pathophysiology of cardiorenal syndrome. Subtotal nephrectomy (NTX) was performed in rats was using a two-step surgical procedure. Twenty-eight days after NTX, myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery. The animals were orally administered vehicle or irbesartan after NTX. The hearts were harvested 28 and 56 days after MI. MI with NTX model rats showed an impaired survival rate and enhanced cardiac inflammation in comparison to MI without NTX rats. Irbesartan tended to improve the survival rate, cardiac inflammation, left ventricular function in MI with NTX rats. Moreover, increases in protein expression levels related to oxidative stress and inflammation observed in the hearts of non-treated MI with NTX rats were attenuated by irbesartan treatment. We conclude that irbesartan has a cardioprotective effect after MI when renal dysfunction is present.

Free Research Field

循環器疾患