Endothelial cellular gap junctions regulate the vascular angiogenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Mie University
• Principal Investigator: Okamoto Takayuki 三重大学, 医学(系)研究科(研究院), 助教 (30378286)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血管生物学 / 血管内皮細胞 / 血管新生 / ギャップ結合

Outline of Final Research Achievements

Gap junctions (GJs) are comprised of members of the connexin (Cx) family and endothelial GJs play an important role in vascular function, stability, and homeostasis. Endothelial dysfunction is related to cardiovascular diseases such as atherosclerosis. The alteration of Cxs expression in vascular endothelial cells contributes to the development of endothelial dysfunction and cardiovascular diseases. We have reported that endothelial GJs regulate vascular inflammation and blood coagulation. In this study, we have identified the role of endothelial GJ in vascular angiogenesis.

Free Research Field

血管生物学