Regulation of vascular endothelial cells by signaling molecules

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461137
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Aichi Medical University
• Principal Investigator: Hisaki Hayashi 愛知医科大学, 医学部, 講師 (30533715)
• Co-Investigator(Kenkyū-buntansha): 中川 修 京都大学, 医学(系)研究科(研究院), その他 (40283593) ; 坂部 正英 奈良県立医科大学, 医学部, 助教 (00525983)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血管新生 / 血管内皮細胞 / VEGFシグナル / G蛋白

Outline of Final Research Achievements

In multicellular organisms, communication between the cells is taken with a variety of signal molecules. Its collapse causes cell dysfunction, eventually leading to a variety of disease. Here, we conducted a study about how to control the blood vessel formation, including angiogenesis, by regulating the cell-to-cell signaling with a new trimeric G-protein -binding protein, AGS8. When expression of AGS8 molecules in vascular endothelial cells was suppressed, basic functions of the endothelial cells (cell growth, movement, lumen formation) was inhibited. Further detailed analysis finally suggested that AGS8 is a new regulatory molecules of VEGF signaling, mainly via acting an appropriate VEGF receptor localization by transporting it from cytosol to cell membrane.

Free Research Field

血管生物学