2016 Fiscal Year Final Research Report
The mechanism of vascular calcification and endothelial dysfunction in chronic kidney disease
| Project/Area Number |
25461140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 慢性腎不全 / 血管病 / 血管内皮機能 / 血管石灰化 |
|---|
| Outline of Final Research Achievements |
BMP receptor signaling has a pivotal role in endothelial dysfunction, in addition to osteogenic differentiation of VSMCs, in the early stage of CKD without vascular remodeling. An increase in PTEN protein is involved in the mechanism by which BMP receptor activation inhibits Akt-eNOS signaling in CKD. Our observations suggest that BMP receptor signaling would be a promising target for the prevention and treatment of both endothelial dysfunction and vascular calcification in the early stage of CKD patients.
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| Free Research Field |
血管生物学
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