2015 Fiscal Year Final Research Report
Development of a novel gene transferable HDL-generating peptide.
| Project/Area Number |
25461141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKU KEIJIRO 福岡大学, 医学部, 教授 (40183371)
MATSUNAGA YOUICHI 徳島文理大学, 薬学部, 教授 (80239053)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ペプチド / アポリポ蛋白 / 高比重リポ蛋白 / 人工HDL / 動脈硬化 / 遺伝子導入 |
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| Outline of Final Research Achievements |
HDL-targeted therapy is in the spotlight for anti-atherosclerosis treatment. An apoA-I mimetic peptides, FAMP5 has been established, and it confirmed that 16-weeks treatment of FAMP5 inhibits aortic atherosclerotic plaque progressions with an improvement of HDL biological functions in ApoE-/- atherosclerotic model. Furthermore, FAMP5-Duo, a novel symmetrical ApoA-I mimetic peptide which has a lysine with the side chain at the C-terminus end was developed. Consequently, it was identified a gene transferring and confirmed the transferred protein expressions by FAMP5-Duo in addition to an improvement of ABCA1-specificity.
A novel gene transferable HDL-generating peptide was developed and it has significant atheroprotective potential and may prove to be a therapeutic tool for atherosclerotic diseases.
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| Free Research Field |
循環器代謝内科学
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