2015 Fiscal Year Final Research Report
A role of anti-CADM-140/MDA5 antibodies in rapidly progressive interstitial lung disease associated with amyopathic dermatomyositis
| Project/Area Number |
25461151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Takuro 新潟大学, 医歯学系, 助教 (00444159)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 皮膚筋炎 / 間質性肺炎 / 抗CADM-140/MDA5抗体 / サイトカイン / CX3CL1 |
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| Outline of Final Research Achievements |
Patients with amyopathic dermatomyositis (ADM) sometimes develop rapidly progressive interstitial lung disease (ILD). Although anti-CADM-140/MDA5 antibody titer could predict the course of ADM-ILD, it is not clear how this antibody is involved in the pathogenesis of the disease. We retrospectively collected clinical records and preserved serum before treatment of consecutive patients with ADM-ILD since 2000 to 2014. Of 13 patients enrolled, four did not respond to therapy and died. The mean anti-CADM-140/MDA5 antibody titer was significantly higher in patients who did not responded (p<0.05). Then we measured serum cytokine/growth factor (GF) protein concentration using a multiplex immunoassay system. Relationship analyses between the antibody titer and each cytokine/GF protein concentration revealed that Spearman's rank correlation coefficients were more than 0.4 in 13 cytokine/GF proteins. The strongest correlation was found between the antibody titer and CX3CL1 (r=0.8897).
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| Free Research Field |
呼吸器内科学
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