The research on disease-specific autoantibodies in diffuse lung diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka University
• Principal Investigator: Kida Hiroshi 大阪大学, 医学系研究科, 助教 (80512988)
• Research Collaborator: KUMANOGOH Atsushi
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: MX1 / INSIP / IPF / surgical lung biopsy / protein array / IIPs / diagnostic criteria / autoantibody

Outline of Final Research Achievements

The current diagnostic criteria for idiopathic interstitial pneumonia (IIPs), which need surgical lung biopsy, sometimes forces patients a big burden. In addition, the diagnosis may change when the underlying diseases, such as collagen vasucular diseases, becomes apparent, during the follow-up period. In a trial to find disease-specific autoantibodies in idiopathic non-specific interstitial pneumonia (INSIP), we found anti-myxovirus resistance-protein 1 (MX1) autoantibody. The titer of anti-MX1 autoantibody elevated in about 17% of patients with chronic fibrosing IIPs. The positivity of anti-MX1 autoantibody was associated with better prognosis among patients with non-idiopathic pulmonary fibrosis (IPF). The current diagnostic criteria for IIPs must be complemented by molecular biomarker, such as the anti-MX1 autoantibody.

Free Research Field

呼吸器内科学