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2016 Fiscal Year Final Research Report

The research on disease-specific autoantibodies in diffuse lung diseases

Research Project

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Project/Area Number 25461157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

Kida Hiroshi  大阪大学, 医学系研究科, 助教 (80512988)

Research Collaborator KUMANOGOH Atsushi  
Project Period (FY) 2013-04-01 – 2017-03-31
KeywordsMX1 / INSIP / IPF / surgical lung biopsy / protein array / IIPs / diagnostic criteria / autoantibody
Outline of Final Research Achievements

The current diagnostic criteria for idiopathic interstitial pneumonia (IIPs), which need surgical lung biopsy, sometimes forces patients a big burden. In addition, the diagnosis may change when the underlying diseases, such as collagen vasucular diseases, becomes apparent, during the follow-up period. In a trial to find disease-specific autoantibodies in idiopathic non-specific interstitial pneumonia (INSIP), we found anti-myxovirus resistance-protein 1 (MX1) autoantibody. The titer of anti-MX1 autoantibody elevated in about 17% of patients with chronic fibrosing IIPs. The positivity of anti-MX1 autoantibody was associated with better prognosis among patients with non-idiopathic pulmonary fibrosis (IPF). The current diagnostic criteria for IIPs must be complemented by molecular biomarker, such as the anti-MX1 autoantibody.

Free Research Field

呼吸器内科学

URL: 

Published: 2018-03-22  

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