Clarification of the pathogenesis and the development of therapeutic modality for fungus associated asthma

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461161
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: MATSUSE Hiroto 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (60336154)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 気管支喘息 / 真菌 / 好中球 / 形質細胞 / 樹状細胞

Outline of Final Research Achievements

It remains a critical clinical issue to clarify the pathogenesis and the development of therapeutic modality for severe asthma with high dose inhaled corticosteroids. Fungus associated asthma is representative of severe asthma. Aspergillus fumigatus induces steroid-resistant neutrophilic inflammation via Th17 in asthmatic airway. Inoculation of plasmacytoid dendritic cell into the airway attenuates neutrophilic airway inflammation thorough downregulation of Th17 and upregulation of Treg and thus could be a potential therapeutic modality for severe fungus associated asthma.

Free Research Field

呼吸器内科学