2016 Fiscal Year Final Research Report
The investigation of non-neuronal cholinergic inflammtation in bronchial asthma
| Project/Area Number |
25461163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 喘息 / アセチルコリン / ムスカリン受容体 / 好酸球 / 気道炎症 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the role of cholinergic inflammation in the pathogenesis of bronchial asthma. We evaluate whether the anti-cholinergic drugs, the muscalinic(M3) receptor antagonists, could control the allergic inflammation, and clarify the mechanisms of effects of M3R antagonists.
Treatment with tiotropium(TIO) on mice sensitized and challenged with OVA reduced eosinophilic inflammation and the Th2 cytokine production, and the expression of ChAT. However the expression of M3r was upregulated with TIO.
In clinical settings, the biomarker of bronchial eosinophilic inflammation in asthma patients (eg FeNO, peripheral eosinophil counts) had not change after addition of tiotropium.
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| Free Research Field |
呼吸器
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