2015 Fiscal Year Final Research Report
Circulating CD27-CD4+T cells in patients with asthma
| Project/Area Number |
25461167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 気管支喘息 |
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| Outline of Final Research Achievements |
We have repoted an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation. Moreover, not only Th2 cells but also a variety of innate subsets of lymphoid cells such as innate lymphoid cells (ILCs), and mucosal-associated invariant T (MAIT) cells are involved in asthma and may have important effector functions in asthmatics. In the present study, we investigated whether the CD27-CD4+T cells ILCs and MAIT cells in the peripheral blood of patients with asthma would be associated with clinical asthma parameters. There were no significant differences in the frequencies of CD27-CD4+T cells, ILCs and MAIT cells between the asthma severity groups. The percentage of activated NK cells, group 1 ILCs, group 2 ILCs, group 3 ILCs and MAIT cells in the peripheral blood of asthmatics were positively correlated with each other, and may orchestrate immune responses, but not behave as an individual population, in asthmatic airway inflammation.
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| Free Research Field |
呼吸器内科
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