The role of proteasome in pulmonary fibrosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Nagai Katsura 北海道大学, 医学(系)研究科(研究院), 客員研究員 (40374293)
• Co-Investigator(Kenkyū-buntansha): TOMARU Utano 北海道大学, 医学研究科(研究院), 准教授 (20360901)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: プロテアソーム

Outline of Final Research Achievements

The activity of 20S proteasome in bronchoalveolar labage fluid tend to be higher in the patients with idiopathic pulmonary fibrosis (IPF) than normal subjects or sarcoidosis patients. Increased proteasome activity suggests a link to fibrotic reaction. In contrast, cigarette smoke-exposed Tg mice with decreased proteasomal chymotrypsin-like activity showed remarkable air space enlargement and increased apoptotic cells compared with wild type controls. Impaired proteasomal activity also enhanced apoptosis and endoplasmic reticulum stress in cigarette smoke extract (CSE)-exposed fibroblastic cells.

Free Research Field

呼吸器内科学