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2015 Fiscal Year Final Research Report

The role of proteasome in pulmonary fibrosis

Research Project

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Project/Area Number 25461181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

Nagai Katsura  北海道大学, 医学(系)研究科(研究院), 客員研究員 (40374293)

Co-Investigator(Kenkyū-buntansha) TOMARU Utano  北海道大学, 医学研究科(研究院), 准教授 (20360901)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsプロテアソーム
Outline of Final Research Achievements

The activity of 20S proteasome in bronchoalveolar labage fluid tend to be higher in the patients with idiopathic pulmonary fibrosis (IPF) than normal subjects or sarcoidosis patients. Increased proteasome activity suggests a link to fibrotic reaction. In contrast, cigarette smoke-exposed Tg mice with decreased proteasomal chymotrypsin-like activity showed remarkable air space enlargement and increased apoptotic cells compared with wild type controls. Impaired proteasomal activity also enhanced apoptosis and endoplasmic reticulum stress in cigarette smoke extract (CSE)-exposed fibroblastic cells.

Free Research Field

呼吸器内科学

URL: 

Published: 2017-05-10  

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