2015 Fiscal Year Final Research Report
Characterization of the role of aldehyde dehydrogensase-2 (ALDH2) and the effect of its human mutant allele (ALDH2*2) on airway stem cells function and predisposition to lung diseases
| Project/Area Number |
25461196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Hegab Ahmed 慶應義塾大学, 医学部, 講師 (00507915)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ALDH2 / aldehyde / lung / stem cell / mitochondria |
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| Outline of Final Research Achievements |
Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High ALDH expression is observed in the stem cells of many organs. A common mutation in ALDH2 gene (ALDH2*2), which affects 40% of East Asians, results in inactivation of the enzyme. This mutation is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer’s diseases, and some cancers. However, the effect of this ALDH2 mutation on the lung has not been thoroughly examined.
We detected several subtle effects of ALDH2 mutation on lungs. Some of these effects are similar to changes observed during normal aging, suggesting a “premature lung aging” effect.
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| Free Research Field |
呼吸器内科
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