The role of a newly discovered Cl ion channel TMEM16A and its targeted therapy in airway hypersecretory diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KONDO Mitsuko 東京女子医科大学, 医学部, 准教授 (50178430)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: TMEM16A / カルシウム活性化クロルイオンチャネル / 気管支喘息 / 杯細胞 / インターロイキン13 / 気道分泌

Outline of Final Research Achievements

TMEM16A has been recently discovered as Ca-activated Cl channel and regulates airway secretion and smooth muscle contraction in asthma. In this study, we showed that TMEM16A inhibitors inhibited the increases in Cl ion transport induced by antigen challenge and Ca-dependent agonist in an asthma model, and that TMEM16A was localized at apical membrane and around mucus in goblet cells. Furthermore, we showed that clarithromycin inhibited TMEM16A in IL-13-induced cultured goblet cell metaplasia. These data suggest that TMEM16A is a new target for the therapy of airway hypersecretory diseases.

Free Research Field

呼吸器内科学