2016 Fiscal Year Final Research Report
The Role of Nitric Oxide in Tracheobronchial Ciliary Motility.
Project/Area Number |
25461203
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
|
Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
Yatera Kazuhiro 産業医科大学, 医学部, 教授 (40341515)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 一酸化窒素 / NO / 一酸化窒素合成酵素 / 線毛 / 原発性線毛運動不全症 / PCD |
Outline of Final Research Achievements |
The role of nitric oxide (NO) and NO synthase (NOS) in ciliary motility is unclear. We investigated the role of NO in ciliary motility using triply NOS knockout mice in the present study. Lipopolysaccharide exposure caused more decrease of ciliary beat frequency (CBF) in triply NOS knockout mice compared with wild mice 24 hours exposure, and pre-treatment of isosorbide dinitrate (NO donor) improved the decrease of CBF. These results suggest the important protective role of NO in ciliary motility.
|
Free Research Field |
呼吸器内科
|