Basic research from kidney developmental biology to clinical nephrology: Organ regeneration and disease models

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461206
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Usui Joichi 筑波大学, 医学医療系, 准教授 (70447340)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 内科 / 腎臓病学 / 再生医学 / 発生・分化 / 病理学

Outline of Final Research Achievements

My research about organogenesis using ES, iPS cells has already been published. The present nephrology research included some issues (Tcf21, VEGF and kidney progenitors). A. Tcf21 expression and functional mechanism in glomerular podocytes of various kideny diseases: Tcf21 expression increased in podocytes of human and rat nephrotic syndrome, and then Tcf21 functionally influenced some cellular phenotypes in murine podocyte cell lone. B. Clinicopathology in VEGF inhibitor-associated kidney diseaes: VEGF inhibitors act to maintain glomerular capillaries, and the failure of this construction induced final glomerular damage. C. In vitro assays for murine nephrogenesis: The establishment of nephrogenesis assay system was continued, then some candidate tools were confirmed.

Free Research Field

内科学