The analysis of the pathophysiology of the Kidney- Gut interaction, the vicious cycle in Chronic kidney disease and dysbiosis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Ohse Takamoto 東京大学, 医学部附属病院, 登録診療員 (10568447)
• Co-Investigator(Kenkyū-buntansha): Hirata Yoshihiro 東京大学, 医学部附属病院, 助教 (10529192) ; Inagi Reiko 東京大学, 医学部附属病院, 特任准教授 (50232509) ; Nangaku Masaomi 東京大学, 医学部附属病院, 教授 (90311620) ; Wada Takehiko 東海大学, 医学部, 准教授 (90447409)
• Research Collaborator: Unuma Satoshi ; Jo Airi
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 慢性腎臓病 / 腸内細菌 / インドキシル硫酸 / 尿毒素

Outline of Final Research Achievements

We evaluated the intestinal environmental change using chronic kidney disease(CKD) rat. One month after the induction of CKD, intestinal Chrostridiaceae was increased, and the intestinal epithelial cells were morphologically changed and the concentration of serum indoxyl sulphate and intestinal indole were elevated. These results indicated that even with the slight kidney damage, these uremic toxins were elevated. Administration of galacto-oligosaccharide(GOS) suppressed the increase of chrostridiaceae and serum uremic toxin, thus it was shown that GOS have the beneficial effect on the improvement of the intestinal flora and uremic condition in CKD.

Free Research Field

腎臓内科学