Research of biomarkers that predict relapse of rapidly progressive glomerulonephritis and reflect long-term prognosis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461213
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Department of Clinical Research, National Hospital Organization Kanazawa Medical Center
• Principal Investigator: Kitagawa Kiyoki 独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, その他 (60436821)
• Co-Investigator(Kenkyū-buntansha): WADA Takashi 金沢大学大学院医薬保健学総合研究科, 血液情報統御学, 教授 (40334784)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 急速進行性腎炎症候群 / 再燃 / 感染症

Outline of Final Research Achievements

The prevention of relapse and infection complications during remission maintenance therapy is required to improve the prognosis of patients with　rapidly progressive glomerulonephritis (RPGN). The clinicopathological characteristics of patients with RPGN were examined to determine the risk factors for relapse or infectious complications after remission induction therapy.
As results of this study, the relation of organ damage severity at remission to relapse has been shown for patients with RPGN. In addition, disease activity at diagnosis and severity of organ damage at remission are related to infectious complications. Further investigations of treatment methods for patients with high disease activity at diagnosis and severe organ damage at remission are required to further improve the prognosis of RPGN patients.

Free Research Field

腎臓病