2015 Fiscal Year Final Research Report
Analysis of the effect of alpha-Klotho protein on the progressions of glomerulonephritis
| Project/Area Number |
25461226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWANO MASAYUKI 福井大学, 医学部, 教授 (20275324)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | α-Klotho / FSP-1 / 慢性腎臓病 / 巣状糸球体硬化症 / ループス腎炎 |
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| Outline of Final Research Achievements |
In this sudy, we revealed the decrease of alpha-Klotho(KL) expression in the kidney was associated with the progression of renal interstitial fibrosis in CKD patients and mouse model of focal segmental glomerulosclerosis(FSGS), via reduced effect on epithelial-mesenchymal transition of tubular epithelial cells by KL. However, the decrease of renal KL expression did not significantly affect the progression of glomerulosclerosis in CKD patients and FSGS model mice. In addition, we revealed the decrease of renal KL expression did not significantly affect the progression of glomerulonephritis in lupus model mice. In summary, KL may have a suppressive effect on renal interstitial fibrosis, but not on glomerulosclerosis and glomerulonephritis.
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| Free Research Field |
内科系臨床医学・腎臓内科学
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