Renal lipid metabolism in extrarenal vascular injuly

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461233
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: Suzuki Yusuke 順天堂大学, 医学(系)研究科(研究院), 准教授 (70372935)
• Co-Investigator(Kenkyū-buntansha): SUGAYA Takeshi 順天堂大学, 医学部, 非常勤講師 (40381561) ; KOBAYASHI Takashi 順天堂大学, 医学部, 助教 (70459056)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 酸化ストレス / L-FABP

Outline of Final Research Achievements

L-FABP has a capacity to bind long-chain fatty acid oxidation products with high affinity, and thus may play roles as an effective endogenous antioxidant in human proximal tubules. We evaluated kidneys for L-FABP Tg and its wild-type littermates (WT) mice at 24hr after middle cerebral artery occlusion and reperfusion (MCAO). There were clear differences in the renal lipid metabolism between WT and L-FABP Tg mice, suggesting that one of underlying mechanisms in brain-renal association.

Free Research Field

腎臓内科学