The role of clock genes in non-dipper hypertension

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hiroshima University
• Principal Investigator: Nakashima Ayumu 広島大学, 原爆放射線医科学研究所, 特任助教 (40448262)
• Co-Investigator(Kenkyū-buntansha): HIGASHI YUKIHITO 広島大学, 原爆放射線医科学研究所, 教授 (40346490) ; MASAKI TAKAO 広島大学病院, 教授 (30397913) ; KAWAMOTO TAKESHI 広島大学, 社会産学連携室, 特任教授 (50224861)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 時計遺伝子 / 血圧 / DEC1 / CLOCK / 日内変動 / Na-K-ATPase

Outline of Final Research Achievements

Tne Na-K-ATPase beta 1 (Atp1b1) mRNA and protein levels in mouse kidney, aorta and heart showed a circadian rhythm. Furthermore, Dec1-deficient mice showed enhanced Atp1b1 expression in these tissues and reduced blood pressure. In contrast, Clock-mutant mice showed reduced Atp1b1 expression and elevated blood pressure.

Free Research Field

腎臓内科