2015 Fiscal Year Final Research Report
Large-scale observational study of hemodialysis patients designed to evaluate associations between practice patterns, biomarkers, and clinical outcomes
| Project/Area Number |
25461257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 慢性腎臓病 / 血液透析 / 生命予後 / 大規模観察研究 |
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| Outline of Final Research Achievements |
In a retrospective cohort study of 2,292 hemodialysis patients, treatment with lanthanum was independently associated with a significant survival benefit in hemodialysis patients with inadequately controlled hyperphosphatemia. We found no significant associations of better glycemic control or use of inhibitors of renin-angiotensin system with improved survival.
We also performed a prospective cohort study: a total of 654 hemodialysis patients were recruited and were prospectively followed for 3 years. Baseline median FGF23 levels and mean soluble Klotho levels were 1,878 pg/ml and 377 pg/ml, respectively. We will evaluate associations of FGF23 levels, soluble Klotho levels, and other patient characteristics with mortality and cardiovascular events.
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| Free Research Field |
腎臓内科学
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