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2015 Fiscal Year Final Research Report

Large-scale observational study of hemodialysis patients designed to evaluate associations between practice patterns, biomarkers, and clinical outcomes

Research Project

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Project/Area Number 25461257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

FUKAGAWA Masafumi  東海大学, 医学部, 教授 (00211516)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords慢性腎臓病 / 血液透析 / 生命予後 / 大規模観察研究
Outline of Final Research Achievements

In a retrospective cohort study of 2,292 hemodialysis patients, treatment with lanthanum was independently associated with a significant survival benefit in hemodialysis patients with inadequately controlled hyperphosphatemia. We found no significant associations of better glycemic control or use of inhibitors of renin-angiotensin system with improved survival.
We also performed a prospective cohort study: a total of 654 hemodialysis patients were recruited and were prospectively followed for 3 years. Baseline median FGF23 levels and mean soluble Klotho levels were 1,878 pg/ml and 377 pg/ml, respectively. We will evaluate associations of FGF23 levels, soluble Klotho levels, and other patient characteristics with mortality and cardiovascular events.

Free Research Field

腎臓内科学

URL: 

Published: 2017-05-10  

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