2015 Fiscal Year Final Research Report
Roles of brain renin-angiotensin system in the chronic blood pressure lowerig effects by renal denervation
| Project/Area Number |
25461258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 交感神経活動 / 高血圧 / レニンーアンジオテンシン系 / （プロ）レニン受容体 |
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| Outline of Final Research Achievements |
This study was planned to investigate the central mechanisms involved in the chronic blood pressure lowering effects by catheter-based renal denervation (RDN). In the HTN-3 Study, however, RDN failed to show significantly greater blood pressure reduction compared with sham procedure in resistant hypertension, directing questions at the blood pressure lowering effects of RDN. Therefore, the study theme was changed to investigation of roles of brain (pro)renin receptor in spontaneously hypertensive rats (SHRs). I am examining if (pro)renin receptor expression is increased in brain of SHRs and the roles of brain (pro)renin receptor in the regulation of blood pressure, brain oxidative stress, vasopressin secretion, sympathetic nerve activity, drinking behavior, and salt preference in these rats.
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| Free Research Field |
高血圧
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