Clinical, pathological and immunological investigation in idiopathic inflammatory myopathies

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461265
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: Tateyama Maki 東北大学, 医学(系)研究科(研究院), 非常勤講師 (90396490)
• Co-Investigator(Kenkyū-buntansha): Fujihara KAZUO 東北大学, 医学系研究科, 非常勤講師 (70280873) ; Misu TATSURO 東北大学, 医学系研究科, 非常勤講師 (00396491)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 特発性炎症性筋疾患 / 皮膚筋炎 / 多発筋炎 / 筋生検 / FDG PET

Outline of Final Research Achievements

Idiopathic inflammatory myopathy (IIM) is an immune-mediated heterogeneous group of disorders characterized by inflammation and muscle fiber necrosis in skeletal muscles. We immunohistochemically analyzed mononuclear cells, blood vessels and lymphatic vessels in the muscles of IIM. We found that the ratio of lymphatic vessels to blood vessels in the lesions was relatively low as compared with non-inflammatory disorders, which may be associated with edema and chronic inflammation in skeletal muscles. We studied a utility of FDG PET in evaluating skeletal muscle inflammation. SUVmax in four limbs in patients with IIM was significantly higher than those in patients with motor neuron diseases. We also evaluated FDG uptake visually (vFDG). vFDG was recognized in two thirds of IIM with varied distribution. Number of vFDG-positive regions was correlated with SUVmax and histological grades of biopsied muscles. FDG PET also visualized lung lesions, swelling of lymph nodes in IIM patients.

Free Research Field

神経内科