A new therapeutic attempt to target neuronal ionic channels for ALS

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461316
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: The University of Tokushima
• Principal Investigator: NODERA Hiroyuki 徳島大学, 大学院医歯薬学研究部, 講師 (40363147)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 筋萎縮性側索硬化症 / イオンチャネル / 神経保護作用

Outline of Final Research Achievements

Neuronal ionic channels have been considered to play a major role in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Medications that influence ionic channels have been administered to SOD1 model mice. There was no significant clinical neuroprotective effect by any of the agent, presumably due to its rapid progression after onset. We developed a new animal model for ALS that has slower onset and progression that mimics human diseases. We continue to test the channel hypothesis with the use of the new animal model.

Free Research Field

臨床神経生理学