2016 Fiscal Year Final Research Report
Considering an objective evaluating system for acute reperfusion therapy utilizing perfusion imaging
| Project/Area Number |
25461320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
|
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| Research Institution | Kyorin University (2014-2016)
Oita University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 灌流画像 / 急性期脳梗塞 / 血行再建療法 |
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| Outline of Final Research Achievements |
Evidence of therapeutic effect of mechanical thrombectomy (MT) for acute ischemic stroke had not been established at 2013, when this study was designed and started. This study aimed to develop novel system that enables objective evaluation of MT using perfusion imaging (CT perfusion: CTP). In 2015, however, 5 randomized controlled trials revealed positive result and showed solid efficacy of MT in patients within 6 hours of stroke onset. Therefore, this study was forced to modify its original plan. During the study period, feasibility of CTP based imaging strategy was confirmed among the consecutive stroke patients admitted in 2016. The threshold level of cerebral blood flow on CTP was estimated as <40% of contralateral side, though the tracer delay (> 2 sec) needed to be corrected.
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| Free Research Field |
臨床神経学
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