A novel electrophysiological method to detect muscle fatigue in myasthenia gravis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Sapporo Medical University
• Principal Investigator: Imai Tomihiro 札幌医科大学, 保健医療学部, 教授 (40231162)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO DAISUKE 札幌医科大学, 医学部, 研究員 (00514556) ; TSUDA EMIKO 札幌医科大学, 医学部, 助教 (90464495)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 重症筋無力症 / 筋疲労 / 興奮収縮連関 / 反復刺激試験 / テタヌス刺激後増強

Outline of Final Research Achievements

This study demonstrated that our novel method using an accelerometer was used to evaluate post-tetanic potentiation of muscle twitch in myasthenia gravis. Significant decrease in post-tetanic potentiation of muscle twitch may be associated with impairment of excitation-contraction coupling in myasthenia gravis. The present method has high sensitivity in detecting impairment of excitation-contraction coupling in myasthenia gravis.

Free Research Field

神経内科学