2015 Fiscal Year Final Research Report
Elucidation of the role of GIP in pancreatic glucagon secretion.
| Project/Area Number |
25461345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The Tazuke Kofukai (2014-2015)
Kyoto University (2013) |
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Principal Investigator |
HAMASAKI Akihiro 公益財団法人田附興風会, 医学研究所第3研究部, 部長 (40456900)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | グルカゴン / インクレチン / GIP / 膵島 / 肥満 |
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| Outline of Final Research Achievements |
We performed basic experiments and clinical studies to elucidate the role of glucose-dependent insulinotropic polypeptide (GIP) in modification of glucagon secretion in diabetes and obesity. We generated and analysed tissue-specific GIP receptor knock-out mice in basic study. We also investigated the relation between glucagon secretion and incretin secretion, and clarified that GIP affected the glucagon secretion especially in postprandial state.
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| Free Research Field |
医歯薬学
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