2015 Fiscal Year Final Research Report
Analysis of role of periostin in proliferative diabetic retinopathy
| Project/Area Number |
25461365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI TAKAKO 昭和大学, 医学部, 准教授 (00175499)
UEDA TOSHIHIKO 昭和大学, 医学部, 講師 (20175219)
IWAI SHINICHI 昭和大学, 薬学部, 教授 (70317519)
SAITO YUTA 昭和大学, 医学部, 講師 (70407477)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIYAMA YOSHIAKI 大阪大学, 医学部, 准教授 (60372611)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ぺリオスチン / 糖尿病網膜症 / 血管新生 / 細胞外基質 |
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| Outline of Final Research Achievements |
Periostin is an extracellular matrix protein that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Recently, it was shown that periostin promotes cardiac repair and remodeling. However, it is unclear that periostin plays a role in neovascularization and fibrovascular proliferation in proliferative diabetic retinopathy (PDR). Therefore, we examined the role of periostin in neovascularization and fibrovascular proliferation in PDR.
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| Free Research Field |
医歯薬学
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