2015 Fiscal Year Final Research Report
Elucidation of the control structure of immunity and the onset prevention by the type 1 diabetes mellitus gene analysis
| Project/Area Number |
25461368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | １型糖尿病 / 膵島自己免疫 / 臓器特異性 |
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| Outline of Final Research Achievements |
Type 1 diabetes mellitus is the organ-specific autoimmune disease that β cell in pancreatic islets is destroyed by immune mechanism and to clarify the mechanism of immunoregulation leads to treatment of type 1 diabetes mellitus.
To clarify the immunoregulation in the type 1 diabetes mellitus, we identify new genes susceptibility to type 1 diabetes mellitus and analyze correlation between autoimmune diseases in different organs.
As a result, we clarified intergenic correlation between autoimmune genes.Then, we established the Mafa(which is the new genes susceptibility to type 1 diabetes mellitus) knockout NOD mouse, it was revealed that the Mafa gene affected the diabetes onset and insulitis.
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| Free Research Field |
糖尿病
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